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Home Product Gallery
KPR

Trade Name: KPR
Generic Name : Ketorolac Tromethamine USP


Composition:

Each tablet contains Ketorolac Tromethamine USP 10 mg.


Pharmacology:

KPR is a potent analgesic agent of the non-steroidal, anti-inflammatory class (NSAID). Its mode of action is to inhibit the cyclo-oxygenase enzyme system and hence prostaglandin synthesis and it demonstrates a minimal anti-inflammatory effect at its analgesic dose.

Ketorolac Tromethamine was rapidly and completely absorbed following oral administration with a mean peak plasma concentration of 0.87 µg/ml occurring an average of 50 minutes after a single 10 mg dose.


Indications:

KPR tablet are indicated for the short-term management of moderate to severe postoperative pain.


Dosage and Administration:

Adults: The recommended oral dose is KPR 10 mg every 4 to 6 hours for pain as required.

KPR tablets are recommended

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for short-term use only (up to 7 days) and are not recommended for chronic use.

 

Not recommended under 16 years of old.


Side Effects:

Gastrointestinal- nausea, vomiting, dyspepsia, diarrhoea, peptic ulcer, haemorrhage, perforation, liver function abnormalities.

CNS/ musculoskeletal- drowsiness, dizziness, sweating, convulsions.

Renal- acute renal failure, flank pain, haematuria.

Other- hypersensitive reactions (anaphylaxis, bronchospasm, laryngeal oedema, purpura, myalgia, post-operative would haemorrhage, injection site pain


Contraindication:

- A history of peptic ulcer or gastrointestinal bleeding

- Suspected or confirmed cerebrovascular bleeding

- Hemorrhagic diatheses, including coagulation disorders

- Patients with hypersensitivity to ketoralac Tromethamine or other NSAIDs and patients in whom aspirin or other prostaglandin synthesis inhibitors include allergic reaction (severe anaphylactic-like reactions have been observed in such patient)

- Patients with the complete or partial syndrome of nasal polyps, angio-edema or bronchospasm

- Concurrent treatment with other NSAIDs, oxpentifylline, probenecid or lithium salts

-

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Hypovolemia from any cause, or dehydration

 

- Moderate or severe renal impairment (serum creatinine > 160 µmol/l)

- A history of asthma

- Patients who have operations with a high risk of hemorrhage or incomplete hemostasis

- Patient on anticoagulants including low-dose heparin (2,500-5,000 units 12 hourly)

- During pregnancy, labor, delivery or lactation

- Children under 16 years of age


Use in Pregnancy and Lactation:

The safety of KPR in human pregnancy has not been established. KPR is therefore contraindicated during pregnancy, labor or delivery.


Storage:

Store in a dry place below 300 C

Keep medicine out of reach of children

This medicine must not be used after the expiry date (EXP) shown on the pack.


Commercial Pack:

Each box contains 2 x 10’s tablets in blister strip.

 


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